[A]Patents Holderof 55 United States granted patents and 30 European, Canadian ,Chinese granted patents & PCT. [B[Recent 4 years publications 1.Liu, Xia; Wang, Zhijun; Xie, Rui; Tang,Pingwah;Yuan, Qipeng. Design,synthesis and biological evaluation of novel carbamodithioates asanti-proliferative agents against human cancer cells. Eur.J. Med. Chem. 2018, 157, 1526-1540. Yun,Fan; Cheng, Chunhui; Li, Jingxuan; Tang,Pingwah;Yuan, Qipeng.TheDiscovery of Ultrasound Irradiation as a Useful Tool forAccelerating Petasis Three component Reaction: Synthesis ofα-Arylglycines.Curr.Org. Synth. 2018, 15, 256-266. Xie,Rui; Tang,Pingwah;Yuan, Qipeng. Rationaldesign and characterization of a DNA/HDAC dual-targetinginhibitor containing nitrogen mustard and 2-aminobenzamidemoieties.MedChemComm.2018, 9, 344-352. Xie,Rui; Li, Yan; Tang,Pingwah;Yuan, Qipeng. Design,synthesis and biological evaluation of novel 2-aminobenzamidescontaining dithiocarbamate moiety as histone deacetylaseinhibitors and potent antitumor agents. Eur.J. Med. Chem. 2018, 143,320-333. Xie,Rui; Li, Yan; Tang,Pingwah;Yuan, Qipeng. Rationaldesign, synthesis and preliminary antitumor activity evaluationof a chlorambucil derivative with potent DNA/HDACdual-targeting inhibitory activity. Bioorg& Med. Chem.Lett.2017, 27,4415-4420. Xie,Rui; Yao, Yue; Tang,Pingwah;Chen, Guangyao; Liu, Xia; Yun, Fan; Cheng, Chunhui; Wu, Xinying;Yuan, Qipeng. Design,synthesis and biological evaluation of novel hydroxamates and2-aminobenzamides as potent histone deacetylaseinhibitors and antitumor agents.Eur.J. Med. Chem. 2017, 134,1-12. Yun,Fan; Cheng, Chunhui; Zhang, Jing; Li, Jingxuan; Liu, Xia; Xie,Rui; Tang,Pingwah;Yuan, Qipeng.
BoricAcid Catalyzed Direct Amidation between Amino-Azaarenes andCarboxylic Acids. Synthesis,2017,49, 1583-1596. Xie,Rui; Shi, Jinghua; Cheng, Chunhui; Yun, Fan; Liu, Xia; Tang,Pingwah;Wu, Xinying; Yang, Ming; Yuan, Qipeng.SynergisticEffect of the Combination of Novel Suberoylanilide HydroxamicAcid Derivatives with Cisplatin onAnti-proliferation of Human Cancer Cells. Med.Chem. 2016, 12, 767-774.Zhang,Jing; Yun, Fan; Xie, Rui; Cheng, Chunhui; Chen, Guangyao; Li,Jingxuan; Tang,Pingwah;Yuan, Qipeng.
Petasisthree-component reaction accelerated by trifluoroaceticacid: synthesis of indoline-derived glycines. TetrahedronLett. 2016, 57, 3916-3919 Tian,Guifang; Tang,Pingwah;Xie, Rui; Cheng, Li; Yuan, Qipeng; Hu, Jing. Thestability and degradation mechanism of sulforaphene in solvents.FoodChem.2016, 199, 301-306. Tian,Guifang; Li, Yuan; Cheng, Li; Yuan, Qipeng; Tang,Pingwah;Kuang, Pengqun; Hu, Jing. Themechanism of sulforaphene degradation to different watercontents. FoodChem.2016, 194, 1022-1027. Xie,Rui; Shi, Jinghua; Qu, Yue; Tang,Pingwah;Wu, Xinying; Yang, Ming; Yuan, Qipeng. Synthesisand Anti-tumor Activities of Novel Phenyl SubstitutedSuberoylanilide Hydroxamic Acid Derivatives Against Human CancerCells. Med.Chem.2015, 11, 636-648. Hu,Jing; Li, Hao; Yang, Yumeng; Wang, Shizeng; Tang,Pingwah; Li,Chunfang; Tian, Guifang; Yuan,
Qipeng.Metabolicregulation of α-linolenic acid on β-carotenesynthesis in Blakeslea trispora revealed by a GC-MS-based metabolomic approach. RSC Advances 2015,78, 63193-63201. Wang,Shizeng; Li, Hao;Fan, Xiaoguang; Zhang, Jingkun; Tang,Pingwah;Yuan, Qipeng. Metabolicresponses in Candida tropicalis to complex inhibitors duringxylitol bioconversion. Fungal GeneticsBioBiology 2015, 82, 1-8. Tian,Guifang; Li, Yuan; Yuan, Qipeng; Cheng, Li; Kuang, Pengqun; Tang,Pingwah. Thestability and degradation kinetics of Sulforaphene inmicrocapsules based on several biopolymers via spray drying.Carbohydrate Polymers 2015, 122, 5-10
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