1. Development ofanticancer peptides into self-delivery anticancer drugs; 2. Design ofpeptide-based materials for drug delivery, such as hydrogels,nanotubes…… 3. Discovery ofnatural protein/peptideswith biological functions, including anticancer, antioxidantactivities and so on. 4. Production ofprotein/peptidedrugs using biological engineering technique.
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Jan.2008-Dec.2012: Stevens Instituteof Technology, Hoboken, New Jersey, USA PhD in ChemicalBiology Sep.2004-Jul.2007: TsinghuaUniversity, Beijing, China MS in Biology Sep.2000-Jul.2004: TsinghuaUniversity, Beijing, China BS in BiologicalScience
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Fude Sun, Xiufang Ding, Lida Xu,Jun F. Liang, LongChen* and Shi-ZhongLuo*. A MolecularDynamics Study of the Short-Helical-Cytolytic Peptide Assemblingand Bioactive on Membrane Interface.Journal of PhysicalChemistry C. 2017, 121:17263-17275. Fude Sun#, LongChen#, XiufangDing, Lida Xu, Xirui Zhou, Peng Wei, Jun F. Liang* and Shi-ZhongLuo*. High-ResolutionInsights into the Stepwise Self-Assembly of Nanofiber fromBioactive Peptides. Journalof Physical Chemistry B.2017, 121: 7421-7430.(Co-first author) Xi-Rui Zhou, Yimeng Cao, QiangZhang, Xi-Bo Tian, He Dong, LongChen*, Shi-ZhongLuo*. Self-assemblynanostructure controlled sustained release, activity andstability of peptide drugs.International Journal ofPharmaceutics. 2017,528: 723-731. Ruru Fan, Yanyan Yuan, QiangZhang, Xi Rui Zhou, Lili Jia, Zhuqing Liu, Changyuan Yu,Shi Zhong Luo*,Long Chen*.Isoleucine/leucineresidues at “a” and “d” positions of aheptad repeat sequence are crucial for the cytolytic activity ofa short anticancer lytic peptide.Amino Acids.2017, 49(1): 193-202. Long Chen,Qiang Zhang, Xiushuang Yuan, Yimeng Cao, Yanyan Yuan, Huiwei Yin,Xiufang Ding, Zhentai Zhu, Shi-Zhong Luo.How Charge DistributionInfluences the Function of Membrane-active Peptides: Lytic orCell-Penetrating?International Journal ofBiochemistry & Cell Biology,2017, 83: 71-75. X.R. Zhou, Q. Zhang, X.B. Tian,Y.M. Cao, Z.Q. Liu, R. Fan, X.F. Ding, Z. Zhu, L.Chen and S.Z. Luo.From a pro-apoptoticpeptide to a lytic peptide: Onesingle residue mutation.Biochim. Biophys.Acta.-Biomembranes.2016, 1858 (8): 1914-1925. Y. Sun#, L.Chen#, F. Sun, X.Tian and S. Luo. NewAmphiphilic N-phosphoryl Oligopeptides Designed for GeneDelivery. InternationalJournal of Pharmaceutics,2014, 468 (1-2):83-90. (Co-first author) L. Chenand J. F. Liang.Peptidefibrils with altered stability, activity, and cellselectivity.Biomacromolecules,2013, 14(7):2326-2331. L.Chen, N.Patrone, J.F.Liang.Peptide self-assembly oncell membranes to induce cell lysis.Biomacromolecules,2012, 13(10):3327-3333. L.Chen and J. F.Liang. MetabolicOligosaccharides Altered Cell Responses to Anticancer Drugs.European Journal ofPharmaceutics and Biopharmaceutics.2012,81: 339-345.
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