An Wenlin

Name

WenlinAn

Gender

Male

College

Collegeof life sciences and technology

Highestdegree

PhD.

ProfessionalTitle

Professor,Doctoralsupervisor

Discipline/Major

AppliedSynthetic Biology

ResearchArea/Direction

Cancertherapy; neurodegeneration; immunology,synthetic biology andbio-safety

OfficePhone

CellPhone

Email

2016880015@mail.buct.edu.cn

ResearchTopics

1. Macrophageengineering

Immunotherapy forcancer and neurodegenerative disease with focus on improvement ofmicroenviornment by macrophage engineering to reduce tumor escapeor loss of function of neuron.

2. Exosome study

1) Mechanism ofexosome formation and its application in the diagnose andtreatment of cancer and neuodegenerative disease

2) Development ofbioactive molecules (natural or unnatural) to be loaded on exosomefor disease treatment

3. Constructionof cyanophage for cyanobacteria control

1) Application ofribosome engineering in the bio-safety of cyanophage

2)Development of bioactive molecules from cyanobacteria for cancertreatment

EducationBackground

2001.11-2005.08PhD in Neuroscience with focus on Neurodegeneration, KarolinskaInstitute,Stockholm, Sweden,

2000.09-2003.07PhD in Neurobiology,CapitalUniversity of Medical Sciences,Beijing, China

1994,09-1997.07MS in Physiology, Capital University of Medical Sciences, Beijing,China,

1989.09-1994.06BS in Preventive Medicine,Nantong Medical School, Jiangsu, China

WorkExperience

2016.09- presentDistinguished Professor, College of Life Science and Technology,Beijing University of Chemical Technology, Beijing China

2010.01-2015.05 Senior Research Scientist, MRC Centre for DevelopmentalNeurobiology,Kings College London, London, United Kingdom

2006.04-2010.12 Career Development Fellow, MRC Laboratory of MolecularBiology,Cambridge, United Kingdom

1997.07-2001.03Research Assistant, Department of Neuropharmacology, XuanwuHospital, Beijing, China

Publications

1. AnWL,Jackson RE,Hunter P, Gogel S, Diepen M, Liu K, Meyer MP., Eickholt BJ.Engineering FKBP-Based Destabilizing Domains to BuildSophisticated Protein Regulation Systems. PLoS One, 2015,10(12): e0145783. (IF:2.8)

2. AnWL,Chin JW.Orthogonal Gene Expression in Escherichia Coli.Methods in Enzymology, 2011,497:115-34. (IF:2.43)

3. GautierA, Nguyen DP., Lusic H, AnWL,Deiters Alexander, Chin JW. Genetically encoded photocontrol ofprotein localization in mammalian cells.JACS,2010,132(12): 4086. (IF:13.8)

4. ZhaoS, Xu W,Jiang W, Yu W, Lin Y, Zhang T, Yao J,Zhou L, Zeng Y, Li H, Li Y, ShiJ,AnWL,Hancock SM., He F, Qin L, Chin JW,Yang P, Chen X, Lei Q, Xiong Y, GuanKL*.Regulation of cellular metabolism by protein lysine acetylation.Science,2010, 327: 1000-1004. (IF:41.06)

5. AnWL,Jason W. Chin. Synthesis of orthogonal transcription-translationnetworks. PNAS, 2009,106: 8477-8482.(IF:9.5)

6. PeiJJ,An WL,Zhou XW, Nishimura T, Norberg J, Benedikz E, Götz J, WinbladB. P70 S6kinase mediates tau phosphorylation and synthesis. FEBSLett.,2006,580:107-114.(IF:3.6)

7. AnWL,Bjorkdahl, Liu R, Cowburn RF, Winblad and Pei JJ. Mechanismof zinc-inducedphosphorylationof p70 S6 kinase and glycogen synthase kinase 3inSH-SY5Y

neuroblastomacells.J. Neurochem.,2005,92:1104-1115(IF:4.6)