Xue Song

Name

姓名

SongXue

Gender

性别

Male

College

学院

Collegeof Life Science & Technology

Highestdegree

最高学历

Ph.D

ProfessionalTitle

职称

AssociateProfessor

Discipline/Major

专业

Biological& Biomedical Science

ResearchArea/Direction

招生研究方向

BiologicalTechnology, Biological Engineering, Medical Science

OfficePhone

办公电话

CellPhone

手机号码

Email

邮箱

xues@mail.buct.edu.cn

ResearchTopics（nomore than 100 words）研究方向

1. Proteinassembling and neurodegenerative diseases

2. Developmentsof peptidic immune checkpoint inhibitors

……

EducationBackground 教育背景

08/2013-05/2018   Ph.D.The Scripps Research InstituteLa Jolla, CA

Major: Biological& Biomedical Science

08/2008-07/2012   B.S.Tsinghua University    Beijing, China

Major: Chemistry– Chemical Biology

WorkExperience 工作经历

BeijingUniversity of Chemical Technology 07/2018-present

• College of LifeScience & TechnologyAssociate Professor

TsinghuaUniversity08/2012-06/2013

• Department ofChemistryResearchAssistant

Publications(nomore than 10 representative publications) 发表文章

1. Chen, C., Ding,X., Akram, N., Xue,S.^*,& Luo, S. Z.^*(2019). Fused in sarcoma: properties, self-assembly andcorrelation with neurodegenerative diseases. Molecules, 24(8),1622.

2. Tararina, M.¹,Xue,S.¹,Smith, L. C., Muellers, S., Miranda, P. O., Janda,K. D.,&Allen,K.^*Crystallography Coupled with Kinetic Analysis Provide MechanisticUnderpinnings of a Nicotine-Degrading Enzyme. Biochemistry,27 (22), 4956-4959.

3. Kallupi M.^1*,Xue,S.¹,Zhou B., George, O.^*,&Janda, K. D. Enzymatic approach to reverse nicotine dependence,decrease compulsive-like intake, and prevent relapse. ScienceAdvances,4 (10), eaat4751.

4. Xue, S.¹,Kallupi M.¹,Zhou B., Smith, L. C., Miranda, P. O., George, O., &Janda, K. D.^*(2018). AnEnzymatic Advance in Nicotine Cessation Therapy. ChemicalCommunications,54 (14), 1686-1689 (front cover).

5. Xue, S.,Seki,H., Remes, M., Šilhár, P.& Janda, K. D.^*(2017). Examination of α-exosite inhibitors againstBotulinum neurotoxin A protease through structure-activityrelationship studies of chicoric acid. Bioorganic& Medicinal Chemistry Letters,27(22), 4956-4959.

6. Bremer, P. T.,Xue,S.,& Janda, K. D.^*(2016). Picolinic acids as β-exosite inhibitors of botulinumneurotoxin A light chain. ChemicalCommunications,52(84), 12521-12524.

7. Seki, H.¹,Xue,S.¹,Pellett, S., Šilhár, P., Johnson, E. A., & Janda,K. D.^*(2016). Cellular Protection of SNAP-25 against BotulinumNeurotoxin/A: Inhibition of Thioredoxin Reductase through aSuicide Substrate Mechanism. Journalof the American Chemical Society, 138(17),5568-5575.

8. Seki, H., Xue,S.,Hixon, M. S., Pellett, S., Remes, M., Johnson, E. A., &Janda, K. D.^*(2015). Toward the discovery of dual inhibitors for botulinumneurotoxin A: concomitant targeting of endocytosis and lightchain protease activity. ChemicalCommunications, 51(28),6226-6229.

9. Xue, S.,Schlosburg, J. E., & Janda, K. D.^*(2015). A new strategy for smoking cessation: Characterization ofa bacterial enzyme for the degradation of nicotine. Journalof the American Chemical Society,137(32), 10136-10139.

10. Xue, S.,Javor, S., Hixon, M. S., & Janda, K. D.^*(2014). Probing BoNT/A protease exosites: implications forinhibitor design and light chain longevity. Biochemistry, 53(43),6820-6824.