Wang Lei

Name

WANGLei

Gender

Male

College

Collegeof Life Science and Technology

Highestdegree

Doctor

ProfessionalTitle

AssociateProfessor

Discipline/Major

Biology

ResearchArea/Direction

NeurodegenerativeDisease, Cancer Biology and Therapy

OfficePhone

CellPhone

Email

wanglei@mail.buct.edu.cn

ResearchTopics

1. Molecularmechanisms of neurodegenerativediseases.

2. Targetscreening for cancer therapy.

3.Immunotherapyfor cancer.

EducationBackground

2008-2010,Visiting Student, Cold Spring Harbor Laboratory, New York, USA

2004-2013,Ph.D.TsinghuaUniversity

2000-2004,B.S.  XiamenUniversity

WorkExperience

2017-2019,Visiting Scholar, UMass Medical School, Massachusetts, USA

2015-Now,AssociateProfessor, College of Life Science and Technology, BeijingUniversity of Chemical Technology

2013-2014,Lecture,College of Life Science and Technology, Beijing University ofChemical Technology

Publications

1  ChenYR,LiYH,HsiehTC,WangCM,ChengKC,WangL,LinTY,CheungCHA ,WuCL,ChiangHC*,Aging-induced Akt activation involves in aging-related pathologiesand A beta-induced toxicity,Aging Cell, 18(4), e12989, 2019.

2  WangLei*,Liang Bin and Zhong Yi*, Reduced EGFR level potentially mediatesthe Aβ42-induced neuronal loss in transgenic fruit fly andmouse, Protein Cell, 4(9), 647–649, 2013.

3  LangMinglin, Fan Qiangwang, WangLei,Zheng Yajun, Xiao Guiran, Wang Xiaoxi, Wang Wei, Zhong Yi, ZhouBing*, Inhibition of human high-affinity copper importer Ctr1orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer’s disease-likesymptoms, Neurobiol Aging, 34(11), 2604-2612, 2013.（co-firstauthor）

4  WangLei,Chiang Hsueh-Cheng, Wu Wenjuan, Liang Bin, Xie Zuolei, YaoXinsheng, Ma Weiwei, Du Shuwen, Zhong Yi*, Epidermal growth factoris a preferred target for treating amyloid-β induced memoryloss, Proc Natl Acad Sci U S A, 109(41), 16743-16748, 2012.

5  LangMinglin, WangLei,Fan Qiangwang, Xiao Guiran, Wang Xiaoxi, Zhong Yi, Zhou Bing*,Genetic inhibition of solute-linked carrier 39 family transporter1 ameliorates Aβ pathology in a Drosophila model ofAlzheimer’s disease, PLoS Genet, 8(4), e1002683,2012. （co-firstauthor）

6 Chiang Hsueh-Cheng, WangLei,Xie Zuolei, Yau Alice, Zhong Yi*, PI3 kinase signaling is involvedin Aβ-induced memory loss in Drosophila, Proc Natl Acad Sci US A, 107(15), 7060-7065, 2010. （co-firstauthor）