Deng Binghua

Name

PingWahTANG

Gender

Male

College

Collegeof life sciences and technology

Highestdegree

Doctorof Science [D.Sc.]

ProfessionalTitle:

Professor

Professor,

Master& PhD adviser

Discipline/Major

OrganicSynthesis & Medicinal Chemistry

ResearchArea/Direction

OrganicSynthesis & Medicinal Chemistry

OfficePhone

CellPhone

Email

tangpw@mail.buct.edu.cn;

sirpwtang@yahoo.com

ResearchTopics

1. OrganicSynthesis of Medicinal Materials, pharmaceutical substance andDrugs;

2. MedicinalChemistry;

3. Novel OrganicMethodology;

4.Boron and organometallic chemistry

EducationBackground

Bs; Ms; Doctor ofchemistry, and Doctor of Sciences from University of Paris,France.

Postdoctoralfellow: Department of Chemistry, Johns Hopkins University {USA}

WorkExperience & Awards

• 2010~present.Specially appointed professor, College of life science andtechnology, Beijing university of chemical technology. Divisionof Organic and Medicinal Chemistry.

• 1998~2009. Srstaff scientist and director of the department of medicinalchemistry in a Biotechnology Company in New York [ EmisphereTechnologies, Inc.]

• 1978~1998. Srstaff scientist. Sr staff scientist in the company worldheadquarter research Laboratory (Section chemistry), EastmanKokak Company, New York

• 1994 Recipientof the Chinese State Administration of Foreign Experts Affairs[SAFEA]“Friendship Award”.

• 2004 Nominee for“United States President’s Green Chemistry ChallengeAward”

• 2013“ExcellentTeacher Award” Beijing University of Chemical Technology.

• Recipient of the111research program from Chinese government SAFEA.

• Languageproficiency:  English, French and Chinese [ read, written &speech]    

Spanish[speech]

Patents&Publications

[A]Patents  

Holderof 55 United States granted patents and 30 European, Canadian ,Chinese granted patents  & PCT.

[B[Recent 4 years publications

1. 1.Liu, Xia; Wang, Zhijun; Xie, Rui; Tang,Pingwah;Yuan, Qipeng. Design,synthesis and biological evaluation of novel carbamodithioates asanti-proliferative agents against human cancer cells. Eur.J. Med. Chem. 2018, 157, 1526-1540.

2. Yun,Fan; Cheng, Chunhui; Li, Jingxuan; Tang,Pingwah;Yuan, Qipeng.TheDiscovery of Ultrasound Irradiation as a Useful Tool forAccelerating Petasis Three component Reaction: Synthesis ofα-Arylglycines.Curr.Org. Synth. 2018, 15, 256-266.

3. Xie,Rui; Tang,Pingwah;Yuan, Qipeng.  Rationaldesign and characterization of a DNA/HDAC dual-targetinginhibitor containing nitrogen mustard and 2-aminobenzamidemoieties.MedChemComm.2018, 9, 344-352.

4. Xie,Rui; Li, Yan; Tang,Pingwah;Yuan, Qipeng. Design,synthesis and biological evaluation of novel 2-aminobenzamidescontaining dithiocarbamate moiety as histone deacetylaseinhibitors and potent antitumor agents. Eur.J. Med. Chem. 2018, 143,320-333.

5. Xie,Rui; Li, Yan; Tang,Pingwah;Yuan, Qipeng. Rationaldesign, synthesis and preliminary antitumor activity evaluationof a chlorambucil derivative with potent DNA/HDACdual-targeting inhibitory activity. Bioorg& Med. Chem.Lett.2017, 27,4415-4420.

6. Xie,Rui; Yao, Yue; Tang,Pingwah;Chen, Guangyao; Liu, Xia; Yun, Fan; Cheng, Chunhui; Wu, Xinying;Yuan,    Qipeng.  Design,synthesis and biological evaluation of novel hydroxamates and2-aminobenzamides as potent  histone deacetylaseinhibitors and antitumor agents.Eur.J. Med. Chem. 2017, 134,1-12.

7. Yun,Fan; Cheng, Chunhui; Zhang, Jing; Li, Jingxuan; Liu, Xia; Xie,Rui; Tang,Pingwah;Yuan, Qipeng.

BoricAcid Catalyzed Direct Amidation between Amino-Azaarenes andCarboxylic Acids. Synthesis,2017,49,

1583-1596.

8. Xie,Rui; Shi, Jinghua; Cheng, Chunhui; Yun, Fan; Liu, Xia; Tang,Pingwah;Wu, Xinying; Yang, Ming; Yuan,  

9. Qipeng.SynergisticEffect of the Combination of Novel Suberoylanilide HydroxamicAcid Derivatives with                               Cisplatin onAnti-proliferation of Human Cancer Cells. Med.Chem.  2016, 12, 767-774.Zhang,Jing; Yun, Fan; Xie, Rui; Cheng, Chunhui; Chen, Guangyao; Li,Jingxuan; Tang,Pingwah;Yuan, Qipeng.

Petasisthree-component reaction accelerated by trifluoroaceticacid: synthesis of indoline-derived glycines.  

TetrahedronLett. 2016, 57, 3916-3919

10. Tian,Guifang; Tang,Pingwah;Xie, Rui; Cheng, Li; Yuan, Qipeng; Hu, Jing. Thestability and degradation mechanism of sulforaphene in solvents.FoodChem.2016, 199, 301-306.             

11. Tian,Guifang; Li, Yuan; Cheng, Li; Yuan, Qipeng; Tang,Pingwah;Kuang, Pengqun; Hu, Jing. Themechanism of sulforaphene degradation to different watercontents. FoodChem.2016, 194, 1022-1027.

12. Xie,Rui; Shi, Jinghua; Qu, Yue; Tang,Pingwah;Wu, Xinying; Yang, Ming; Yuan, Qipeng. Synthesisand Anti-tumor Activities of Novel Phenyl SubstitutedSuberoylanilide Hydroxamic Acid Derivatives Against Human CancerCells.  Med.Chem.2015, 11, 636-648.

13. Hu,Jing; Li, Hao; Yang, Yumeng; Wang, Shizeng; Tang,Pingwah; Li,Chunfang; Tian, Guifang; Yuan,

Qipeng.Metabolicregulation of α-linolenic acid on β-carotenesynthesis in Blakeslea trispora revealed by a         GC-MS-based metabolomic approach. RSC Advances 2015,78, 63193-63201.

14. Wang,Shizeng; Li, Hao;Fan, Xiaoguang; Zhang, Jingkun; Tang,Pingwah;Yuan, Qipeng. Metabolicresponses in Candida tropicalis to complex inhibitors duringxylitol bioconversion.  Fungal GeneticsBioBiology 2015, 82, 1-8.

15. Tian,Guifang; Li, Yuan; Yuan, Qipeng; Cheng, Li; Kuang, Pengqun; Tang,Pingwah. Thestability and degradation kinetics of Sulforaphene inmicrocapsules based on several   biopolymers via spray drying.Carbohydrate Polymers 2015, 122, 5-10