Chen Long

Name

姓名

LongChen

陈龙

Gender

性别

Male

男

College

学院

Collegeof Life Science and Technology

生命科学与技术学院

Highestdegree

最高学历

Ph.D

博士

ProfessionalTitle

职称

AssociateProfessor

副教授

Discipline/Major

专业

PharmaceuticalEngineering/ChemicalBiology

化学生物学

ResearchArea/Direction

招生研究方向

Peptidedrugs, Drug delivery, Anticancer drugs

多肽药物，药物递送，抗肿瘤药物

OfficePhone

办公电话

CellPhone

手机号码

Email

邮箱

chenlong@mail.buct.edu.cn

ResearchTopics（nomore than 100 words）研究方向

1. Development ofanticancer peptides into self-delivery anticancer drugs;

2. Design ofpeptide-based materials for drug delivery, such as hydrogels,nanotubes……

3. Discovery ofnatural protein/peptideswith biological functions, including anticancer, antioxidantactivities and so on.

4. Production ofprotein/peptidedrugs using biological engineering technique.

EducationBackground 教育背景

Jan.2008-Dec.2012:

Stevens Instituteof Technology, Hoboken, New Jersey, USA

PhD in ChemicalBiology

Sep.2004-Jul.2007:

TsinghuaUniversity, Beijing, China

MS in Biology

Sep.2000-Jul.2004:

TsinghuaUniversity, Beijing, China

BS in BiologicalScience

WorkExperience 工作经历

Sept.2013-Present:  AssociateProfessor

Collegeof LifeScienceand Technology,Beijing University of Chemical Technology

Publications(nomore than 10 representative publications) 发表文章

1. Fude Sun, Xiufang Ding, Lida Xu,Jun F. Liang, LongChen* and Shi-ZhongLuo*. A MolecularDynamics Study of the Short-Helical-Cytolytic Peptide Assemblingand Bioactive on Membrane Interface.Journal of PhysicalChemistry C. 2017, 121:17263-17275.

2. Fude Sun#, LongChen#, XiufangDing, Lida Xu, Xirui Zhou, Peng Wei, Jun F. Liang* and Shi-ZhongLuo*. High-ResolutionInsights into the Stepwise Self-Assembly of Nanofiber fromBioactive Peptides. Journalof Physical Chemistry B.2017, 121: 7421-7430.(Co-first author)

3. Xi-Rui Zhou, Yimeng Cao, QiangZhang, Xi-Bo Tian, He Dong, LongChen*, Shi-ZhongLuo*. Self-assemblynanostructure controlled sustained release, activity andstability of peptide drugs.International Journal ofPharmaceutics. 2017,528: 723-731.

4. Ruru Fan, Yanyan Yuan, QiangZhang, Xi Rui Zhou, Lili Jia, Zhuqing Liu, Changyuan Yu,Shi Zhong Luo*,Long Chen*.Isoleucine/leucineresidues at “a” and “d” positions of aheptad repeat sequence are crucial for the cytolytic activity ofa short anticancer lytic peptide.Amino Acids.2017, 49(1): 193-202.

5. Long Chen,Qiang Zhang, Xiushuang Yuan, Yimeng Cao, Yanyan Yuan, Huiwei Yin,Xiufang Ding, Zhentai Zhu, Shi-Zhong Luo.How Charge DistributionInfluences the Function of Membrane-active Peptides: Lytic orCell-Penetrating?International Journal ofBiochemistry & Cell Biology,2017, 83: 71-75.

6. X.R. Zhou, Q. Zhang, X.B. Tian,Y.M. Cao, Z.Q. Liu, R. Fan, X.F. Ding, Z. Zhu, L.Chen and S.Z. Luo.From a pro-apoptoticpeptide to a lytic peptide: Onesingle residue mutation.Biochim. Biophys.Acta.-Biomembranes.2016, 1858 (8): 1914-1925.

7. Y. Sun#, L.Chen#, F. Sun, X.Tian and S. Luo. NewAmphiphilic N-phosphoryl Oligopeptides Designed for GeneDelivery. InternationalJournal of Pharmaceutics,2014, 468 (1-2):83-90. (Co-first author)

8. L. Chenand J. F. Liang.Peptidefibrils with altered stability, activity, and cellselectivity.Biomacromolecules,2013, 14(7):2326-2331.

9. L.Chen, N.Patrone, J.F.Liang.Peptide self-assembly oncell membranes to induce cell lysis.Biomacromolecules,2012, 13(10):3327-3333.

10. L.Chen and J. F.Liang. MetabolicOligosaccharides Altered Cell Responses to Anticancer Drugs.European Journal ofPharmaceutics and Biopharmaceutics.2012,81: 339-345.