Shuobo Shi

Name

姓名

Shuobo Shi

Gender

性别

Male

College

学院

International Research Center for Soft Matter

Highest degree

最高学历

PhD

Professional Title

职称

Professor

Discipline/Major

专业

Biochemical Engineering,

Biological Engineering

Research Area/Direction

招生研究方向

Metabolic engineering, synthetic biology

Email

邮箱

shishuobo@mail.buct.edu.cn

Research Topics（no more than 100 words）研究方向

1. Metabolic engineering of microbial cell factories to produce biofuels/chemicals

2. Development of genome engineering and synthetic biology tools

3. Engineering cells to efficiently utilize non-natural substrates

Education Background 教育背景

Ph.D.: in Biochemical Engineering, Tianjin University, P.R. China

Thesis: “System metabolic engineering of Bacillus subtilis for improved riboflavin production”

Work Experience 工作经历

1. 2017-now  Principal Investigator & Professor, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China

2. 2013-2017  Scientist I, Metabolic Engineering Research Lab, Agency for Science, Technology and Research (A*STAR), Singapore

3. 2009-2012  Postdoctoral Researcher, Department of Chemical and Biological Engineering, Chalmers University of Technology, Sweden

Publications(no more than 10 representative publications) 发表文章

1.  Qun Yue#, Jie Meng#, Yue Qiu, Miaomiao Yin, Liwen Zhang, Weiping Zhou, Zhiqiang An, Zihe Liu, Qipeng Yuan, Wentao Sun, Chun Li, István Molnár*, Yuquan Xu*, Shuobo Shi* (2023) A polycistronic system for multiplexed and precalibrated expression of multigene pathways in fungi. Nat Commun, 14: 4267. (Highlighted and featured by Editor as one of the 50 best papers recently published in "Biotechnology and methods" area).

2.  Jinyu Fu, Linghao Zhang, Yanlin Long, Zihe Liu, Geng Meng, Huimin Zhao, Xin Su,* Shuobo Shi*. (2023) Multiplexed CRISPR-based nucleic acid detection using a single Cas protein. Analytical Chemistry, 95: 16089–16097

3.  Genlai Dong, Shijie Xu, Shuobo Shi* (2023) De novo biosynthesis of free vaccenic acid with a low content of oleic acid in Saccharomyces cerevisiae. Journal of Agricultural and Food Chemistry, 71: 16204–16211

4.  Nailing Qi, Wentao Ding, Genlai Dong, Zhihui Wang,Shuobo Shi* (2023) De novo bio-production of odd-chain fatty acids in Saccharomyces cerevisiae through a synthetic pathway via 3-hydroxypropionic acid. Biotechnol. Bioeng. 120: 852-858

5.  Jie Meng, Yue Qiu, Yueping Zhang, Huimin Zhao, Shuobo Shi*(2023) CMI: CRISPR/Cas9 based efficient multiplexed integration in Saccharomyces cerevisiae. ACS Synthetic Biology. 12: 1408 (cover paper)

6.  Juan Octavio Valle-Rodríguez, Verena Siewers, Jens Nielsen, Shuobo Shi*(2023). Directed evolution of a wax ester synthase for production of fatty acid ethyl esters in Saccharomyces cerevisiae. Applied Microbiology and Biotechnology, 107: 2921–2932.

7.  Weibo Qiao, Shijie Xu, Zihe Liu, Xiao.Fu, Huimin Zhao, Shuobo Shi* (2022). Challenges and opportunities in C1-based biomanufacturing. Bioresour. Technol. 364: 128095. (TOP)

8.  Wentao Ding, Qiongyu Meng, Genlai Dong, NailingQi, Huimin Zhao*, Shuobo Shi* (2022) Metabolic engineering of threonine catabolism enables Saccharomyces cerevisiae to produce propionate under aerobic conditions. Biotechnology Journal, 17:2100579. (ESI Highly Cited Papers)

9. Shuobo Shi, Zhihui Wang, Lirong Shen, Han Xiao (2022) Synthetic biology: pushing the new frontier of food production. Trends in Biotechnology. 40: 781. (TOP)

10.  Yang Zhang, Jie Peng, Huimin Zhao, Shuobo Shi* (2021) Engineering Oleaginous Yeast Rhodotorula toruloides for Overproduction of Fatty Acid Ethyl Esters. Biotechnology for Biofuels, 14:115. (TOP)