Xinxiao Sun

Name

姓名

Xinxiao Sun

Gender

性别

Male

College

学院

College of Life Science and Technology

Highest degree

最高学历

Ph.D

Professional Title

职称

Professor

Discipline/Major

专业

Biochemical Engineering

Research Area/Direction

招生研究方向

Metabolic engineering

Synthetic biology

Bioinformatics

Email

邮箱

sunxx@mail.buct.edu.cn

Research Topics（no more than 100 words）研究方向

His main research interests are metabolic engineering and synthetic biology, focusing on the key issue of "directional regulation of metabolic flux", proposing a multi-level research idea of strengthening the target metabolic flow, enhancing the directional distribution of metabolic flow in terms of intra-pathway cofactor recycle, parallel pathway convergence, inter-cellular metabolic synergy and mutual benefit of growth production, and designing efficient synthetic pathways for chemicals such as dencichine and glutaric acid, constructed a stable self-regulated co-culture system, and realized the industrial production of inositol and 5-hydroxytryptophan.

1. Metabolic engineering

2. Synthetic biology

3. Bioinformatics

Education Background 教育背景

 2004.09-2008.06   Beijing University of Chemical Technology   Bachelor’ s Degree in Pharmaceutical Engineering

2008.09-2015.06  Beijing University of Chemical Technology   Ph.D degree in Chemical Engineering and Technology  

Work Experience 工作经历

2015.07–2020.12       College of Life Science and Technology，Associate Professor

2021.01–Now            College of Life Science and Technology，Professor

Publications(no more than 10 representative publications) 发表文章

1.Sun W, Yin Q, Wan H, Gao R, Xiong C, Xie C, ..., Sun X* &Chen S*. Characterization of the horse chestnut genome reveals the evolution of aescin and aesculin biosynthesis. Nature communications 14, 6470. (2023)

2. Li W, Zhou Z, Li X, Ma L, Guan Q, Zheng G, ..., Sun X* & Yuan Q*. Biosynthesis of plant hemostatic dencichine in Escherichia coli. Nature Communications, 13(1), 5492. (2022)

3.Sun M, Yang M, Li S, Wang C, Zhang F, Xu B, ... Sun X*, Yuan Q* & Liu H. Photothermal Lysis of Engineered Bacteria to Modulate Amino Acid Metabolism against Tumors. Advanced Functional Materials, 33(13), 2212226. (2023)

4.Li X, Zhou Z, Li W, Yan Y, Shen X, Wang J, Sun X*, Yuan Q*. Design of stable and self-regulated microbial consortia for chemical synthesis. Nature Communications, 13, 1554. (2022)

5.Li W, Ma L, Shen X, Wang J, Feng Q, Liu L, Zheng G, Yan Y, Sun X*, Yuan Q*. Targeting metabolic driving and intermediate influx in lysine catabolism for high-level glutarate production. Nature Communications 10, 3337 (2019).

6.Li W, Shen X, Wang J, Sun X*, Yuan Q*. Engineering microorganisms for the biosynthesis of dicarboxylic acids. Biotechnology  Advances 48, 107710 (2021).

7.Wu Y^#, Sun X^#, Lin Y, Shen X, Yang Y, Jain R, Yuan Q, Yan Y*. Establishing a synergetic carbon utilization mechanism for non-catabolic use of glucose in microbial synthesis of trehalose. Metabolic Engineering 39, 1-8 (2017).

8.Chen Z, Sun X*, Li Y, Yan Y, Yuan Q*. Metabolic engineering of Escherichia coli for microbial synthesis of monolignols. Metabolic Engineering 39, 102-109 (2017).

9.Li Y, Wang M, Zhao Q, Shen X, Wang J, Yan Y, Sun X*, Yuan Q*. Shunting phenylacetic acid catabolism for tropone biosynthesis. ACS Synthetic Biology 8, 876-883 (2019).

10.Li X, Chen Z, Wu Y, Yan Y, Sun X*, Yuan Q*. Establishing an Artificial Pathway for Efficient Biosynthesis of Hydroxytyrosol. ACS Synthetic Biology 7, 647-654 (2018).